New York's seven-day average case rate has jumped by 43% since Thanksgiving.
As the COVID-19 pandemic has swept the globe, more than 5.3 million people have died from the disease worldwide, including over 797,000 Americans, according to real-time data compiled by Johns Hopkins University's Center for Systems Science and Engineering.
Just 60.7% of the population in the United States is fully vaccinated against COVID-19, according to data from the Centers for Disease Control and Prevention.
More than 50 million Americans have now received a COVID-19 booster shot, according to newly updated federal data.
More than half of fully vaccinated people 65 years and older have received a booster.
On average, about 2.03 million total shots are being administered each day, the data shows. More than half -- 1.1 million -- are booster doses.
-ABC News' Arielle Mitropoulos
The PolicyLab at Children's Hospital of Philadelphia predicts "significant" case growth across much of the U.S. over the next four weeks.
According to forecasters, large metropolitan areas, particularly in the Northeast, are seeing significant case growth following Thanksgiving.
Cases in the New York City area are expected to at least double through December, the forecasters said.
Metropolitan areas in New Jersey, Delaware and North Carolina are expected to see a rapid case increase, forecasters said.
The forecasters also noted a "sudden" increase in cases in Florida in the last two weeks.
-ABC News' Arielle Mitropoulos
There have been no deaths and one hospitalization among the 43 known omicron patients in the U.S., according to a new report from the Centers for Disease Control and Prevention.
According to public health experts, early indications show omicron could cause less severe disease than prior variants, but it's still too early to say for sure. It's also possible that omicron only appears less severe because many of the people who have been infected have been vaccinated, younger adults.
-ABC News' Sony Salzman
The U.S. is now reporting more than 118,000 new cases each day -- up by nearly 85% since late October, according to federal data.
On average, more than 7,400 Americans are being admitted to the hospital with COVID-19 each day -- a nearly 16% increase in the last week, while pediatric hospital admissions have skyrocketed by more than 40%, the data shows.
More than 7,600 Americans have died from COVID-19 in the last week. West Virginia currently has the country's highest death rate, followed by Wyoming, Montana and Tennessee.
-ABC News' Arielle Mitropoulos
