No one was injured, according to the Qatari Ministry of Defense.
President Donald Trump announced "major combat operations" against Iran on Saturday, with daytime strikes in the joint U.S.-Israel attack targeting military and government sites, officials said.
On Sunday, Iranian state television confirmed that Ayatollah Ali Khamenei was among those killed by airstrikes in Tehran on Saturday.
Iran is responding to the U.S.-Israeli operation with missile and drone attacks targeting Israel, regional U.S. bases and Gulf nations. American diplomatic facilities have also been attacked.
In Lebanon, Israel is intensifying its long-running strike campaign against the Iranian-aligned Hezbollah militia.
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The U.S. strikes involve a mix of U.S. aircraft and Tomahawk cruise missiles fired by U.S. Navy ships in the region according to a U.S. official.
-ABC News' Luis Martinez
In a post on social media, the Pentagon posted the name of the military operation: "Operation Epic Fury."
Prime Minister Benjamin Netanyahu in his first remarks on the strikes said in a statement that Israel and the U.S. "embarked on an operation to remove the existential threat posed by the terrorist regime in Iran."
Calling it Operation "The Roar of the Lion," Netanyahu thanked President Donald Trump "for his historic leadership."
Netanyahu added: "This murderous terrorist regime must not be armed with nuclear weapons that would allow it to threaten all of humanity."
He called on the Iranian people to "throw off the yoke of tyranny," saying, "Our joint action will create the conditions for the courageous Iranian people to take their destiny into their own hands."
Three U.S. officials confirm that the operation is expected to potentially last for several days with targets including Islamic Revolutionary Guard Corps military sites, government buildings, Iranian intelligence assets and defense installations.
