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After two Palestinians were killed in the West Bank during an ongoing Israel Defense Forces operation in the West Bank on Thursday, the United Nations said it is "appalled" by the "brazen killing by Israeli border police."

"Impunity for Israel security forces' unlawful use of force, and ever-growing Israeli settler violence, must end. UN High Commissioner for Human Rights Volker Turk urges independent, prompt and effective investigations into the killings of Palestinians, and that those responsible for violations be held fully to account," a spokesperson for the U.N. high commissioner for human rights said in a statement.

Mahmoud Qasim Abdallah, 26, and Youssef Ali Youssef Essa'sa, 37, were shot by Israeli forces in Jenin, the Palestinian General Authority for Civil Affairs said. Israeli forces shot at two suspects during an ongoing operation in Jenin, the IDF said in a statement on Thursday.

The IDF and the Israeli police said in a statement the two people targeted were "wanted individuals affiliated with a terror network."

The ongoing Israeli operation in the West Bank has continued to intensify in recent days. Israeli forces conducted airstrikes as a part of the operation on Wednesday, and Israeli air forces were again used on Thursday to "provide aerial assistance to the soldiers on the ground," the IDF said in a separate statement about the ongoing operation.

Two Palestinians were killed in the West Bank during an ongoing Israeli Defense Forces operation, the Palestinian General Authority for Civil Affairs said in a statement Thursday.

Mahmoud Qasim Abdallah, 26, and Youssef Ali Youssef Essa'sa, 37, were shot by Israeli forces in Jenin, the Palestinian General Authority for Civil Affairs said. Israeli forces shot at two suspects during an ongoing operation in Jenin, the IDF said in a statement.

The incident is "under review" by the IDF commanders on the ground, the IDF statement added.

The IDF and the Israeli police said in a statement the two people targeted were "wanted individuals affiliated with a terror network."

"The forces entered the area, enclosed the structure in which the suspects were located, and initiated a surrender procedure that lasted several hours. Following the use of engineering tools on the structure, the two suspects exited," the IDF said. "Following their exit, fire was directed toward the suspects."

The ongoing Israeli operation in the West Bank has continued to intensify in recent days. Israeli forces conducted airstrikes as a part of the operation on Wednesday, and Israeli air forces were again used on Thursday to "provide aerial assistance to the soldiers on the ground," the IDF said in a separate statement about the ongoing operation.

Israeli forces "searched over 220 sites, questioned dozens of suspects and apprehended several wanted individuals" on the first day of the West Bank operation, the IDF said.

-ABC News' Jordana Miller and Nasser Atta

The Israel Defense Forces said Thursday that military, police and intelligence forces searched more than 220 sites in the occupied West Bank in the previous 24 hours, as Israel launched what it called a major "counterterrorism operation" in the Palestinian territory.

The operation is being carried out in the Jenin and Nablus areas, Israeli officials have said.

"The security forces searched over 220 sites, questioned dozens of suspects and apprehended several wanted individuals," the IDF said in a post to X. Security forces also recovered weapons and money, the IDF said.

"The operation will expand as required," the statement said.

Israeli forces conducted airstrikes in the West Bank overnight Tuesday into Wednesday in another sign of escalation of violence in the area in recent weeks.

Israeli forces called the operation that began overnight a "broad counterterrorism operation" being carried out in "northern Sameria," which is the biblical name for the area used by Israeli officials. The operation is being carried out in Jenin and Nablus in the West Bank.

At least three people have been killed in the operation, the Israel Defense Forces said in a statement. The IDF referred to these three people as "terrorists."

-ABC News' Jordana Miller