Israel-Iran updates: Iran launches more missiles at Israel, sirens sound in Tel Aviv and Jerusalem

Iran has confirmed the deaths of the top general of Iran's Revolutionary Guard as well as several top scientists, according to the general staff of the armed forces of the Islamic Republic of Iran.

Hossein Salami, the IRGC commander-in-chief has been confirmed to have been killed along with Gholamali Rashid, deputy chief of the general staff of the armed forces of Iran, Dr. Mohammad Mehdi Tehranchi, physicist and president of Islamic Azad University, and nuclear scientist Dr. Fereydoun Abbasi, Iran said.

Ali Shamkhani, a member of the Expediency Discernment Council of Iran was seriously injured but is still alive, Iran said, and the status of Dr. Abdolhamid Minouchehr, the head of nuclear engineering at Iran's Shahid Beheshti University, is yet to be confirmed.

Meanwhile, Iranian State TV is reporting several residential neighborhoods and apartment complexes were hit and says that there were casualties of civilians and children in the attack, though numbers have yet to be confirmed.

Israel Defense Forces spokesperson Brigadier General Effie Defrin says that “Iran launched approximately 100 UAVs towards Israeli territory, which we are working to intercept.”

Israel says it is planning to use its air defenses to intercept the drones as air raid sirens can be heard blaring across the country which is under a state of emergency that was imposed overnight.

The state of emergency means nobody one is allowed to be out on the streets and almost all businesses, including schools, offices and supermarkets, have also been shut as the airspace over Israel is closed.

President Trump spoke to Fox News' Bret Baier via phone after the Israeli strikes on Tehran and said that his administration was aware of the strikes but was not involved militarily, and that he hopes Iran will return to negotiate a deal.

“Iran cannot have a nuclear bomb, and we are hoping to get back to the negotiating table. We will see. There are several people in leadership that will not be coming back," Trump told Baier.

-ABC News' Alex Ederson

In a statement early Friday morning, Israeli Prime Minister Benjamin Netanyahu released a statement calling the strikes "successful."

Translated from Hebrew, Netanyahu said, "We are after a very successful opening strike. With God's help, we are going to have many more achievements."