Israel-Iran updates: Iran launches more missiles at Israel, sirens sound in Tel Aviv and Jerusalem

Israel said it has killed “over 20 commanders in the Iranian regime’s security apparatus,” since the start of the Israeli operation early Friday morning local time.

Iranian Armed Forces General Staff Gholam-Reza Marhabi, who “was considered Iran’s most senior intelligence officer,” the Commander of the IRGC’s Surface-to-Surface Missile Array Mohammad Bagheri and the IRGC’s Air Force Commander Amir Ali Hajizadeh were among those killed in the operation by Israel, according to the Israel Defense Forces.

Bagheri “oversaw most of Iran’s surface-to-surface and cruise missile capabilities,” the IDF said. "Bagheri managed Iran’s firepower systems and played an active role in the decision-making processes behind Iran’s attacks on Israel in April and October 2024."

Hajizadeh "and several other senior officials," were killed in an underground headquarters in Tehran, the IDF said.

-ABC News' Jordana Miller

At least 78 people were killed and another 320 were been injured in Israeli attacks across Iran, Iran’s permanent representative to the United Nations Amir Saeid Iravani told the Security Council.

Dozens of locals gathered to look at damage caused by one of Iran's missiles in Ramat Gan, a city of about 170,000 people which neighbors Tel Aviv.

Police have a large block cordoned-off as officials work at the scene where there is crumbled concrete, twisted metal and flattened cars. White dust coats everything; the trees, the ground, the entire block. Several buildings are destroyed.

"I feel like the collateral damage,” Rony Armon told ABC News. "The walls were shaking. We never imagined that it was so close."

His family took cover in a shelter Friday night as Iran rained missiles down on the city.

"I look horrified at what happens in Gaza, but now it’s in my back door, which is totally different story," he said.

“I hope it will stop as soon as possible,” Armon added. "I think it’s another round of stupid wars that are initiated by my government, in my name. And it’s useless.”

-ABC News' Dana Savir, Marcus Moore and Jordana Miller

The Iranian Ministry of Foreign Affairs commented on the possibility of continuing talks with the U.S., which were meant to be held in Oman on Sunday.

"Citing the messages and statements of the US President, Araghchi considered the hostile actions of the Zionist regime as the result of direct support from Washington and emphasized that the continuation of indirect negotiations between Iran and the US in a situation where the barbarity of the Zionist regime continues is unjustifiable," the ministry said in a statement.

The ministry's spokesperson Esmaeil Baqaei said Iran's participation in Sunday's talks is still "unclear."

"It is still unclear what decision we will make on Sunday in this regard," Baqaei said in an interview on Iranian state TV Saturday.

"The other side did something that practically rendered negotiations and dialogue meaningless. It is not possible for you to simultaneously claim negotiations and dialogue to reach an understanding on an issue and at the same time divide the work and allow a racist regime to violate the country's territorial integrity," Baqaei said.

-ABC News' Nasser Atta