Hurricane Isaias updates: At least 4 dead as Isaias downgraded to post-tropical cyclone

The remnants of Hurricane Isaias continue to sweep across parts of the Southeast on Saturday afternoon bringing heavy rain and strong wind gusts.

The greatest risk of heavy rain and flash flooding includes parts of northeastern Georgia and the western Carolinas, where a level 3 of 4 flash flood threat is in place. Significant flash flooding is possible in these areas, which includes Athens and Gainesville in Georgia; Greenville, South Carolina; and Asheville, North Carolina.

A level 2 of 4 risk for flash flooding remains in place across a large swath of the Southeast, including much of Georgia and the Carolinas into tonight.

Wind alerts in effect for parts of the Southeast and up across the central Appalachian Mountains, with wind gusts of 40-50 mph possible.

The strongest winds through tonight will be focused across the higher elevations of the central Appalachians, where gusts up to 60 mph are possible.

Flood Watches remain posted from northern Florida to Virginia.

Through Saturday evening, the heaviest rain will be focused over eastern Georgia and the western Carolinas.

Tonight, it will be focused over a large swath of the Appalachian Mountain region, from western North Carolina into southwestern Virginia.

At least two storm-related deaths are now confirmed in Escambia County, Florida, Gov. Ron DeSantis said in a press conference Saturday

"One individual in Escambia County had a tree fall on his home and tragically was killed. And another one, unfortunately, died inside of his garage. And when they went to find them, the generator was running," DeSantis said.

"From the structural perspective, I think our structures handled the storm very well. The problem is that the storm knocked over a lot of trees, and so your house, the roof probably didn't blow off on this. But if the tree fell on your house, then obviously that's very difficult situation," Governor DeSantis said.

Destin-Fort Walton Airport in Pensacola remains closed, but the governor noted that this could change "pretty soon."

DeSantis that new flooding is expected in the coming days as rivers are expected to crest.

"I know that this was a storm that had a broad impact. It's not just Okaloosa County where it made landfall, and we understand that there was damage that that stretches really from the Alabama-Florida line all the way into the far eastern parts of the Florida Panhandle. So we'll be working with the locals to be able to provide the support that they need," DeSantis said.

-ABC News' Victoria Arancio

At least two people are dead in Alabama after Hurricane Isaias made landfall, according to local officials.

A tree fell on a house causing the first of the two deaths, according to the Jefferson County Emergency Management Agency.

"Across Jefferson County, we have received multiple reports of trees damaging homes. At this time, we are not aware of any additional storm-related injuries," Jefferson County EMA said in a statement Saturday.

A woman has been confirmed dead in Florida after a tree fell on a house, fatally injuring her while she was inside, according to the Escambia County Sheriff.

The sheriff's office asked residents to stay off roadways so Florida Power & Light can work on getting power restored.