Sen. Thom Tillis, R-N.C., questioned Judge Jackson about a case when she was considering a prisoner's release due to the outbreak of the COVID-19 pandemic.

After reading a line taken out of context from an opinion where she declined the blanket release of inmates, Tillis asked Jackson if her "empathy" and "compassion" could lead her to release criminals.

Jackson noted Tillis was not reading her whole statement and that she decided not to release the defendant in that case. She added that she speaks directly to defendants for public safety and accountability.

"Congress also tells us that one of the purposes of punishment is rehabilitation. My attempts to communicate directly with defendants is about public safety," she said. "It is to our entire benefit to ensure people who come out stop committing crimes."

"You have to go away understanding that I am imposing consequences for your decision to engage in criminal behavior," she added. "I was the one in my sentencing practices who explained those things in an interest of furthering Congress's direction that we’re supposed to be sentencing people so that they can ultimately be rehabilitated to the benefit of society as a whole."

Tillis replied that more than half of the people she sentenced have, "statistically speaking," re-offended and "were back in prison."

-ABC News' Trish Turner

Addressing limitations on power, Sen. Jon Ossoff, D-Ga., raised a ruling by Judge Jackson for the D.C. Circuit Court in 2019, in which she determined that former Trump White House counsel Don McGahn had to comply with a congressional subpoena and wrote, "Presidents are not kings."

He asked Jackson to explain that observation and what bulwarks in the Constitution protect against abuse of executive power.

"Our constitutional scheme, the design of our government, is erected to prevent tyranny," Jackson said. "The framers decided after experiencing monarchy, tyranny, and the like, that they were going to create a government that would split the powers of a monarch in several different ways."

She walked through the separation of powers and called them both "crucial to liberty" and "consistent" with her judicial methodology.

"It is what our country is founded on. And it's important, as consistent with my judicial methodology, for each branch to operate within their own sphere. That means, for me, that judges can't make law. Judges shouldn't be policymakers. That's a part of our constitutional design, and it prevents our government from being too powerful and encroaching on individual liberty," she said.

Sen. Jon Ossoff, D-Ga., allowed Judge Jackson the opportunity to speak again to her family’s ties to law enforcement and public service as some Republicans have attempted to paint her as "soft on crime" and taken issue with her record defending Guantanamo Bay detainees.

Jackson recalled how after her younger brother graduated from Howard University, he followed in the footsteps of her uncles and became a police officer in Baltimore. In the wake of the Sept. 11 attacks, he joined the Army and deployed twice, not as an officer, though he could have with his college degree, but on the frontlines.

"That's the kind of person my brother is. That's the kind of service that our family provides, and for me, what that meant was an understanding that to defend our country and its values, we also needed to make sure that when we responded as a country to the terrible attacks on 9/11, we were upholding our constitutional values -- that we weren't allowing the terrorists to win by changing who we are," she said.

"And so I joined with many lawyers during that time who were helping the courts figure out the limits of executive authority consistent with what the framers have told us is important, the limitations on government," Jackson continued. "I worked to protect our country. My brother worked on the front lines, and it was all because public service is important to us."

Senate Judiciary Chairman Dick Durbin, D-Ill., using his privilege as chairman, delivered an opening statement to begin Wednesday's session, coming to the defense of Judge Jackson after he said Republicans unfairly attacked her record on Tuesday.

Durbin said some Republican senators used the hearings as "an opportunity to showcase talking points for the November election" and sought to "put in context" some of their accusations.

Rejecting what he called the "stereotype" that Jackson is "soft on crime," he raised her endorsements from the Fraternal Order of Police and the International Association of Chiefs of Police and repeated that she is in the "mainstream" of sentencing when it comes to child pornography cases.

"I also think it's ironic that the senator from Missouri who unleashed this discredited attack refuses to acknowledge that his own choice for a federal judge in the Eastern District of Missouri has done exactly what you did," Durbin said, referring to an orchestrated attack from Republican Sen. Josh Hawley.

Durbin also defended her record representing Guantanamo detainees which several Republicans took issue with, reminding senators of the 6th Amendment to the Constitution which they serve.

"Your nomination turned out to be a testing ground for conspiracy theories and culture war theories. The more bizarre charges against you and your family, the more the social media scoreboard lit up yesterday," Durbin said. "I'm sorry that we go to go through this. These are not theories in the mainstream of America but they have been presented here as such."

"You are a respected, successful woman of color. You've been approved three times by this committee for increasingly significant judicial assignments," he added. "America is ready for this Supreme Court glass ceiling to finally shatter, and you, Ketanji Brown Jackson are the person to do it."