Ahead of his major tariff announcement, Trump is urging Republican senators to oppose a Democratic resolution to block levies against Canada.

Trump went so far as to call out some members of his party by name in a new post on his social media platform on Wednesday morning.

"Mitch McConnell of Kentucky, Susan Collins of Maine, Lisa Murkowski of Alaska, and Rand Paul, also of Kentucky, will hopefully get on the Republican bandwagon, for a change," he wrote on his social media platform. He added the bill "is just a ploy of the Dems to show and expose the weakness of certain Republicans, namely these four, in that it is not going anywhere because the House will never approve it and I, as your President, will never sign it."

To the people of the Great States of Kentucky, Alaska, and Maine, please contact these Senators and get them to FINALLY adhere to Republican Values and Ideals. They have been extremely difficult to deal with and, unbelievably disloyal to hardworking Majority Leader John Thune, and the Republican Party itself. MAKE AMERICA GREAT AGAIN!" he continued.

President Donald Trump on Wednesday will unveil what are expected to be broad-based "reciprocal tariffs" on imports as part of his "America First" agenda.

It's a moment months in the making for the president, who has repeatedly billed it as "Liberation Day" from dependence on foreign goods -- but is also a significant political gamble as economist fear moves could cause the economy to slide into a recession and markets seesawed ahead of Wednesday's announcement, slated for 4 p.m. ET, after the markets end trading.

Read more about the upcoming announcement here.

Two months after the initial "Fork in the Road" emails were sent to federal employees across the government, numerous agencies have begun rolling out independent, agency-specific deferred resignation programs -- separate from the DOGE-led effort that sparked court challenges and outrage from critics, according to emails and sources with knowledge of the plans.

Last week, the Department of Defense announced its own DRP, offering civilian employees the opportunity to resign with full pay and benefits through Sept. 30.

Over the last few days, other agencies have begun offering similar programs, including the Department of Energy, the General Services Administration, the Small Business Administration, the Department of Transportation, and the Department of Housing and Urban Development, according to internal emails reviewed by ABC News.

A letter to HUD employees this week announcing its program, calling it "DPR 2," acknowledged that employees were skeptical of the "validity" of the initial rollout of the deferred resignation program given it was during Congress' budget negotiations, which prevented some from participating.

Agencies are setting different deadlines to accept the offers -- the Department of Transportation set a deadline of just before midnight on April 7, HUD is giving employees until April 11 and GSA is giving employees until April 18.

-ABC News' Will Steakin and Soo Rin Kim

Mexican President Claudia Sheinbaum said during her daily press conference Tuesday that Mexico will give its answer to Trump’s tariffs on Thursday or Friday.

"Our response to the tariff situation that may arise, we have to wait because we continue to hold dialogues," Sheinbaum said in Spanish. "It is the Mexico Plan, a plan to strengthen the national economy."

"It is not a conflict with the United States, but a strengthening of the national economy," she added. "We are always open to the world."

-ABC News' Anne Laurent and Ellie Kaufman